Photograph: Imperial College London/PAĮach psilocybin session – which lasted six hours, including a three- to four-hour “trip” for those on the high dose – was supervised by at least two mental health professionals, with the participants lying on their back, propped up by pillows and listening to emotionally evocative neoclassical music.Īll participants received psychological therapy the day after a psilocybin session, as well as a phone or video call in the week after the first dose.
The day after the first dose of psilocybin, this group began a daily dose of escitalopram, the strength of which increased over time.Īdults with moderate to severe major depressive disorder were randomly allocated to receive two 25mg doses of psilocybin three weeks apart. This was to ensure any differences in outcomes between the groups would not simply be down to the expectation of being given psilocybin. The other 29 participants were given two very low, or “inactive”, doses of psilocybin three weeks apart. The day after the first dose of psilocybin, this group began a daily placebo. Over the six-week trial, 30 out of 59 adults with moderate to severe major depressive disorder were randomly allocated to receive two 25mg doses of psilocybin three weeks apart – a dose that Carhart-Harris said was high enough to produce the kind of experiences often described as existential or even “mystical”.
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The £1m trial builds on previous work by the team exploring how psilocybin affects the brain, and an earlier clinical trial in which the drug helped alleviate treatment-resistant depression in 12 patients. “We strongly believe that the … psychotherapy component is as important as the drug action.” “That would be an error of judgment,” he said. To learn more about our books and journals programs, please visit us at our website.Dr Robin Carhart-Harris, co-author of the study: ‘The results signal hope that we may be looking at a promising alternative treatment for depression.’ Photograph: Imperial College London/PA UNC Press publishes over 100 new books annually, in a variety of disciplines, in a variety of formats, both print and electronic. Many of our journal issues are also available as ebooks. UNC Press publishes journals in a variety of fields including Early American Literature, education, southern studies, and more.
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